Category Archives: Clinical Studies

Invited Speech at NIH Pain Workshop Washington DC Nov 15th 2018 (Video Cast)

Invited Speaker at NIH Workshop: Discovery and Validation of Biomarkers to Develop Non-Addictive Therapeutics for Pain Session: Emerging Tools and Approaches in Biomarker Discovery and Development Title: Predictive validity of human Laser-EPs in extended phase-I IND analgesic research Look Video … Continue reading

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Important invitation by NIH to participate in “Discovery of Biomarkers to Develop Transformational Non-Addictive Therapeutics for Pain”

Workshop at Marriott Wardman-Park, Washington, DC – November 14-15, 2018 with Participants from NIH, NINDS, FDA, Academia and Pharma

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A Phase I, randomized, double-blind, laser evoked potential study to evaluate the analgesic/anti-hyperalgesic effect of ASP9226, a state-dependent N-type voltage-gated calcium channel inhibitor, in healthy male subjects

K. Schaffler, A. Fakhoury, W. He, P. Passier, K. Tracy, J. Paul in print, Pain Medicine, DOI:10.1093/pm/pnx338

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A Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Phase I Study of Analgesic/Antihyperalgesic Properties of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Healthy Female Subjects

Klaus Schaffler, MD, Ashraf Yassen, PhD, PharmD, Peter Reeh, MD, PhD, and Paul Passier, PhD ASP8477 Paper_FAAH_LEP_Caps Pain Medicine Dec 2017   DOI:10.1093/pm/pnx281

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Investigation of the predictive validity of laser- EPs in normal, UVB-inflamed and capsaicin-irritated skin with four analgesic compounds in healthy volunteers

BCJP_Pred.Validity_LEP_03.2017_T1 Klaus Schaffler, Laurent B. Nicolas, Andreas Borta, Tobias Brand, Peter Reitmeir, Robert Roebling and Joachim Scholpp in Br J Clin Pharmacol (Jan 2017) DOI:10.1111/bcp.13247 Abstract: AIMS The aim of the present study was to assess the predictivity of laser-(radiant-heat)-evoked … Continue reading

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HPR Poster Presentation at the 15th World Congress on Pain in Buenos Aires 2014

First Clinical Translation of the Anti-Nociceptive/Anti-Hyperalgesic Efficacy of a T-Type Calcium Channel Modulator (Z944) – Using Laser Evoked Potentials and VAS in UV-B and Capsaicin Irritated Skin in Healthy Humans K. D. Schaffler Germany,Head, HPR-Human Pharmacodynamic Res., Munich; M. S. … Continue reading

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HPR Dr. Schaffler GmbH in cooperation with Zalicus announces positive results of Z944 Phase 1B Clinical Study in Pain

Positive results of Z944 Phase 1B Clinical Study in Pain Efficacy Signals in Inflammatory and Neuropathic Pain Observed Second U.S. Patent Issues for Z944 Providing Exclusivity to 2029 Munich, Germany – June 17th, 2014 – HPR Dr. Schaffler GmbH, a … Continue reading

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An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UV(B)-inflamed and normal skin

Schaffler K, Reeh P, Duan WR, Best AE, Othman AA, Faltynek CR, Locke C, Nothaft W. Br J Clin Pharmacol. 75:2 / 404–414 2012 Jul 10.2012 DOI: 10.1111/j.1365-2125.2012.04377.x. Abstract AIMS: Laser (radiant-heat) evoked potentials (LEPs) from vertex-EEG Peak-to-Peak (PtP) amplitude were … Continue reading

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Dose-response relationship after single oral dose administrations of morphine and oxycodone using laser-evoked potentials on UVB- and capsaicin-irritated skin in healthy male subjects

Eef Hoeben, Johan W. Smit, David Upmalis, Sarah Rusch, Klaus Schaffler, Peter Reitmeir, Bernhard Mangold    http://dx.doi.org/10.1016/j.pain.2012.04.018 in PAIN 153 (2012) 1648–1656 (full paper here:) Abstract: The aim of the study was to evaluate the analgesic/antihyperalgesic efficacy and to establish the … Continue reading

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HPR Dr. Schaffler GmbH Corporate Video…

https://www.youtube.com/watch?feature=player_embedded&v=XxqTiHlgJAE

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