Author Archives: hprdsadmin

Invited Speech at NIH Pain Workshop Washington DC Nov 15th 2018 (Video Cast)

Invited Speaker at NIH Workshop: Discovery and Validation of Biomarkers to Develop Non-Addictive Therapeutics for Pain Session: Emerging Tools and Approaches in Biomarker Discovery and Development Title: Predictive validity of human Laser-EPs in extended phase-I IND analgesic research Look Video … Continue reading

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Important invitation by NIH to participate in “Discovery of Biomarkers to Develop Transformational Non-Addictive Therapeutics for Pain”

Workshop at Marriott Wardman-Park, Washington, DC – November 14-15, 2018 with Participants from NIH, NINDS, FDA, Academia and Pharma

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A Phase I, randomized, double-blind, laser evoked potential study to evaluate the analgesic/anti-hyperalgesic effect of ASP9226, a state-dependent N-type voltage-gated calcium channel inhibitor, in healthy male subjects

K. Schaffler, A. Fakhoury, W. He, P. Passier, K. Tracy, J. Paul in print, Pain Medicine, DOI:10.1093/pm/pnx338

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A Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Phase I Study of Analgesic/Antihyperalgesic Properties of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Healthy Female Subjects

Klaus Schaffler, MD, Ashraf Yassen, PhD, PharmD, Peter Reeh, MD, PhD, and Paul Passier, PhD ASP8477 Paper_FAAH_LEP_Caps Pain Medicine Dec 2017   DOI:10.1093/pm/pnx281

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Investigation of the predictive validity of laser- EPs in normal, UVB-inflamed and capsaicin-irritated skin with four analgesic compounds in healthy volunteers

BCJP_Pred.Validity_LEP_03.2017_T1 Klaus Schaffler, Laurent B. Nicolas, Andreas Borta, Tobias Brand, Peter Reitmeir, Robert Roebling and Joachim Scholpp in Br J Clin Pharmacol (Jan 2017) DOI:10.1111/bcp.13247 Abstract: AIMS The aim of the present study was to assess the predictivity of laser-(radiant-heat)-evoked … Continue reading

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