Author Archives: Klaus Schaffler

About Klaus Schaffler

Dr. med. Klaus Schaffler (MD) has been specializing in the electrophysiology and pharmacology of the human central nervous system (CNS) – as well as in the field of human experimental pain research. During this development process, HPR Dr. Schaffler GmbH has issued over 175 presentations/ publications (sharing more than 50 on pain/ analgesia) and has conducted more than 150 phase-I studies with quite different objectives.

HPR Poster Präsentation und Konferenzteilnahme am 15. IASP Schmerzkongress in Buenos Aires 2014

FIRST CLINICAL TRANSLATION OF THE ANTI-NOCICEPTIVE/ANTI-HYPERALGESIC EFFICACY OF A T-TYPE CALCIUM CHANNEL MODULATOR (Z944) – USING LASER EVOKED POTENTIALS AND VAS IN UV-B AND CAPSAICIN IRRITATED SKIN IN HEALTHY HUMANS Author Block: K. D. Schaffler Germany,Head, HPR-Human Pharmacodynamic Res., Munich; … Continue reading

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HPR Poster Presentation at the 15th World Congress on Pain in Buenos Aires 2014

First Clinical Translation of the Anti-Nociceptive/Anti-Hyperalgesic Efficacy of a T-Type Calcium Channel Modulator (Z944) – Using Laser Evoked Potentials and VAS in UV-B and Capsaicin Irritated Skin in Healthy Humans K. D. Schaffler Germany,Head, HPR-Human Pharmacodynamic Res., Munich; M. S. … Continue reading

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HPR Dr. Schaffler GmbH führt klinische Studie Phase 1B an Z944 in Zusammenarbeit mit Zalicus durch…

Positive Ergebnisse mit Z944 Phase 1B Schmerz-Studie Laden Sie die aktuelle Pressemitteilung zur Studie an Z944 herunter oder besuchen Sie unsere englische Seite zu diesem Thema.

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HPR Dr. Schaffler GmbH in cooperation with Zalicus announces positive results of Z944 Phase 1B Clinical Study in Pain

Positive results of Z944 Phase 1B Clinical Study in Pain Efficacy Signals in Inflammatory and Neuropathic Pain Observed Second U.S. Patent Issues for Z944 Providing Exclusivity to 2029 Munich, Germany – June 17th, 2014 – HPR Dr. Schaffler GmbH, a … Continue reading

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An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UV(B)-inflamed and normal skin

Schaffler K, Reeh P, Duan WR, Best AE, Othman AA, Faltynek CR, Locke C, Nothaft W. Br J Clin Pharmacol. 75:2 / 404–414 2012 Jul 10.2012 DOI: 10.1111/j.1365-2125.2012.04377.x. Abstract AIMS: Laser (radiant-heat) evoked potentials (LEPs) from vertex-EEG Peak-to-Peak (PtP) amplitude were … Continue reading

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Dose-response relationship after single oral dose administrations of morphine and oxycodone using laser-evoked potentials on UVB- and capsaicin-irritated skin in healthy male subjects

Eef Hoeben, Johan W. Smit, David Upmalis, Sarah Rusch, Klaus Schaffler, Peter Reitmeir, Bernhard Mangold    http://dx.doi.org/10.1016/j.pain.2012.04.018 in PAIN 153 (2012) 1648–1656 (full paper here:) Abstract: The aim of the study was to evaluate the analgesic/antihyperalgesic efficacy and to establish the … Continue reading

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HPR Dr. Schaffler GmbH Firmenpräsentation…

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HPR Dr. Schaffler GmbH Corporate Video…

https://www.youtube.com/watch?feature=player_embedded&v=XxqTiHlgJAE

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American Society for Clinical Pharmacology and Therapeutics 2012 ASCPT Annual Meeting, March 12-17, 2012 in National Harbor, Maryland, US

Wir (Andrea Edginton and Klaus Schaffler) hatten eine Poster-Präsentation (in Zusammenarbeit zwischen der School of Pharmacy, University of Waterloo, Ontario, Kanada und HPR München) im Rahmen des 2012 ASCPT (American Society for Clinical Pharmacology and Therapeutics) Annual Meeting, am 12.-17. … Continue reading

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American Society for Clinical Pharmacology and Therapeutics 2012 ASCPT Annual Meeting, March 12-17, 2012 in National Harbor, Maryland, US

We (Andrea Edginton and Klaus Schaffler) had a poster presentation – (in cooperation between School of Pharmacy, University of Waterloo, Ontario, Canada and HPR Munich) at the 2012 ASCPT/ American Society for Clinical Pharmacology and Therapeutics Annual Meeting, March 12-17, … Continue reading

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