Human Pharmacodynamic Research GmbH has built a successful name in pharmacodynamic research since 1976, based in Munich, Germany. For more than 40 years now, the company’s founder, Dr. med. Klaus Schaffler, has been specializing in electrophysiology and pharmacology of the human central nervous system as well as in the field of human experimental pain research. During this time, HPR has issued over 175 presentations & publications, sharing more than fifty on pain alone. Up to the present date the company issued more than 150 phase-I studies as PI with different objectives.

Former successful research areas of HPR within the central nervous system have been vigilance, psycho-motor activity (oculomotor and eye-hand coordination by ODT & PTT), cognition, interactions (drug-drug, alcohol-drug), skeleto-motor related conducts (EMG+dynamometry and tremor), hypoxia, motion sickness and more, all of which you can investigate from our list of publications.

Today, the CRO HPR is focused on Phase-I clinical trials in human pharmacodynamics and in combined pd/pk approaches for national and international pharmaceutical companies.