Company

HPR Dr. Schaffler GmbH – a Contract Research Organization (CRO) – has built a successful name in pharmacodynamic research since 1976 (first named LfE). HPR (Human Pharmacodynamic Research) opened a new business location in Aschheim-Dornach in the vicinity of Munich, Germany end of 2010 (HPR_NewBuilding, see groundfloor right wing), after the earlier Kronstadterstrasse and Peschelanger locations. Since more than 35 years now, the founder of Human Pharmacodynamic Research, Dr. med. Klaus Schaffler, MD Klaus Schaffler LinkedIn, has been specializing in the electrophysiology and pharmacology of the human central nervous system (CNS) – as well as in the field of human experimental pain research. During this development process, HPR Dr. Schaffler GmbH has issued over 175 presentations/ publications (sharing more than 50 on pain/ analgesia) and has conducted more than 150 phase-I studies as PI with quite different objectives.

The CRO HPR is focused on Phase-I clinical trials in human pharmacodynamics and in combined pd/pk approaches for national and international pharmaceutical companies. Hereby, HPR has elaborated – besides other CNS-research approaches in vigilance and psychomotorics – a special model, the “Laser-Pain-Algesimetry”, under consideration of different sensitized and non-sensitized states of the skin (e.g. normal, UV and capsaicin skin) to examine and analyze the effect of analgesic/anti-hyperalgesic and anti-inflammatory compounds in humans. This well-developed and validated method of  pain measurement guarantees a highly objective and quantitative approach to investigate the (systemical and topical) efficacy of analgesics by examining brain responses to repetitive nociceptive stimuli via “Evoked Potentials” (see figure left) – recorded on-line in real-time from Vertex-EEG position. This strong, unique and systematic methodological feature of HPR Dr. Schaffler GmbH, together with flexible and creative study designs, as well as quick statistical data analysis and reporting, enables Human Pharmacodynamic Research (HPR) to provide customers with outstanding examination and analysis of medication effects on CNS and pain processing – also based on an existing large data base of prior investigated (typical and atypical) analgesics and topicals in different compound groups (see Database Analgesics LEP_HPR), and also based on a large scale of experimental and practical trial experience and competence in this field.

Further research areas of HPR within the central nervous system are vigilance, psycho-motor activity (oculomotor and eye-hand coordination, ODT, PTT), cognition, interactions (drug-drug, alcohol-drug), skeleto-motor issues (EMG+dynamometry and tremor), hypoxia, motion sickness and even more, all of which you can investigate further from our complete lists of publications and presentations.